ism2, Yoann Coquerel

Centre national de la recherche Scientifique

Dr. Yoann COQUEREL

AMU iSm2 Service 531
Campus Scientifique de St Jérôme
13397 Marseille cedex 20

Téléphone : 0491 28 9088

Fax : 0491 28 9187

Courriel : yoann.coquerel@univ-amu.fr

Autre site Web :

Parcours

2001 : Doctorat en sciences, Université Joseph Fourier - Grenoble 1, Dr. A. E. Greene et Prof. J.-P. Deprés (UMR 5616)
2002 : Lauréat du prix Fournier - SFC (anciennement prix de thèse)
2001-2002 : Post-doctorat, Florida State University, USA, Prof. R. A. Holton
2002-2003 : A.T.E.R., Université Joseph Fourier - Grenoble 1, Dr. A. E. Greene et Prof. J.-P. Deprés (UMR 5616)
2003 : Entrée au CNRS (Chargé de Recherche), Université d’Aix-Marseille III, Prof. J. Rodriguez (UMR 6178)
2009 : Habilitation à diriger des Recherches

Enseignements

Thématiques

Synthèse totale de produits naturels :
- Sesquiterpènes et diterpènes polycycliques naturels
- Spiroacétals naturels
Méthodologie de synthèse organique éco-compatible:
- Utilisation de l'activation par micro-ondes
- Transformations domino et multicomposé
Organocatalyse énantiosélective
- Activation par donneurs de liaisons hydrogène
- Activation par les carbènes N-hétérocycliques (NHCs)
- Activation par les bases de Lewis
- Aminocatalyse

Responsabilités administratives

- Responsable de la chimiothèque de l'iSm2 (2004-présent)
- Membre élu du conseil de laboratoire de l'iSm2 (2008-2012)
- Membre du Conseil d'Animation Scientifique de la Fédération des Sciences Chimiques de Marseille (2004-2007)

Publications

Titre	Auteurs
Cascade Reactions Forming both C–C Bond and C–Heteroatom Bond	D. Bonne, T. Constantieux, Y. Coquerel, J. Rodriguez, in Stereoselective Organocatalysis: From C–C to C–Heteroatom Bond Formation, Ed.: R. Rios Torres; John Wiley & Sons, Hoboken, NJ, 2013, Chap. 9, in press.
Reactions Involving an ?,?-Unsaturated Compound as Electrophilic Component with the Michael Addition as the Key Step	J. Rodriguez, D. Bonne, Y. Coquerel, T. Constantieux, in Multicomponent Reactions, Science of Synthesis Reference Library, Ed.: T. J. J. Mu?ller; Thieme, Stuttgart, 2013, Chap. 4.1, in press.
Microwave-Assisted Stereoselective Synthesis	Y. Coquerel, E. Colacino, J. Rodriguez, J. Martinez, F. Lamaty, in Stereoselective Synthesis of Drugs and Natural Products, Eds: V. Andrushko, N. Andrushko; Wiley- Blackwell, Hoboken, NJ, 2013, Chap. 5, in press.
Michael Addition-Initiated Sequential Reactions from 1,3-Dicarbonyls for the Synthesis of Polycyclic Heterocycles	X. Bugaut, D. Bonne, Y. Coquerel, J. Rodriguez, T. Constantieux, Curr. Org. Chem. 2013, accepted.
Practical and Efficient Organocatalytic Enantioselective ?- Hydroxyamination Reactions of ?-Ketoamides	D. Mailhol, J.-C. Castillo, K. Mohanan, R. Abonia, Y. Coquerel, J. Rodriguez, ChemCatChem 2013, 5, 1192-1199
Stereoselective Multiple Bond-Forming Transformations (MBFTs): The Power of 1,2- and 1,3-Dicarbonyl Compounds	D. Bonne, T. Constantieux, Y. Coquerel, J. Rodriguez, Chem.–Eur. J. 2013, 19, 2218-2231.
Syntheses and Applications of Functionalized Bicyclo[3.2.1]octanes: Thirteen Years of Progress	M. Presset, Y. Coquerel, J. Rodriguez, Chem. Rev. 2013, 113, 525-595.
Expeditious Synthesis of the Cores of Naturally Occurring Cyclic Polyethers using a Divergent Ring Rearrangement Metathesis Strategy	P. Escavabaja, J. Viala, Y. Coquerel, J. Rodriguez, Adv. Synth. Catal., 2012, 354, 3200-3204.
Enantioselective Organocatalytic Michael Addition of Cyclobutanones to Nitroalkenes	D. Mailhol, M. M. Sanchez Duque, W. Raimondi, D. Bonne, T. Constantieux, Y. Coquerel, J. Rodriguez, Adv. Synth. Catal.,2012, 354, 3523-3532.
Transition-Metal-Free alpha-Arylation of beta-Keto Amides via an Interrupted Insertion Reaction of Arynes	Kishor Mohanan, Yoann Coquerel, Jean Rodriguez, Org. Lett. 2012, 14, 4686-4689.
Catalyst- and Halogen-Free Regioselective Friedel–Crafts ?-Ketoacylations	Kishor Mohanan, Marc Presset, Damien Mailhol, Yoann Coquerel, Jean Rodriguez Chem. Eur. J. 2012, 18: 9217–9220
Microwave-Assisted Domino Benzannulation of ?-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones	Juan-Carlos Castillo, Marc Presset, Rodrigo Abonia, Yoann Coquerel, Jean Rodriguez Eur. J. Org. Chem. 2012, 2338-2345
Asymmetric organocascades involving the formation of two C–heteroatom bonds from two distinct heteroatoms	Damien Bonne , Thierry Constantieux , Yoann Coquerel andJean Rodriguez, Org. Biomol. Chem., 2012,10, 3969-3973
Single-Step Metallocatalyzed and Organocatalyzed Enantioselective Construction of Bicyclo[3.2.1]octanes	M. PRESSET, Y. COQUEREL, J. Rodriguez, ChemCatChem (Highlight) 2012, 4, 172-174.
Stereoselective Multicomponent Reactions: from Simple 1,3-Dicarbonyls to Functionalized Chiral Heterocycles	D. Bonne, Y. Coquerel, T. Constantieux, J. Rodriguez in Targets in Heterocyclic Systems - Chemistry and Properties, Vol. 15, Eds.: O. A. Attanasi, D. Spinelli; Societa? Chimica Italiana, Roma, 2011, pp. 140-163.
Combination of Rearrangement with Metallic and Organic Catalyses: a Step- and Atom-economical Approach to alpha-Spirolactones and -lactams	Thomas Boddaert, Yoann Coquerel, Jean Rodriguez Eur. J. Org. Chem. 2011, 5061-5070.
1,3-Dipolar Cycloaddition of Hydrazones with ?-Oxo-ketenes: A Three-Component Stereoselective Entry to Pyrazolidinones and an Original Class of Spirooxindoles	Marc Presset, Kishor Mohanan, Marie Hamann, Yoann Coquerel, and Jean Rodriguez Org. Lett. 2011, 13, 4124-4127
Diazo Transfer Reactions to 1,3-Dicarbonyl Compounds with Tosyl azide	Marc Presset, Damien Mailhol, Yoann Coquerel, Jean Rodriguez Synthesis 2011, 2549-2552
Consecutive Reactions with Sulfoximines: Straightforward Synthesis of Substituted 5,5-Spiroketals	Vellaisamy Sridharan, Nikolay Vologdin, Marie-Alice Virolleaud, Cyril Bressy, Gaëlle Chouraqui, Laurent Commeiras, Jean-Luc Parrain, Damien Bonne,Yoann Coquerel, Jean Rodriguez Synthesis 2011, 2085-2090.
N-Heterocyclic Carbene-Catalyzed Michael Additions of 1,3-Dicarbonyl Compounds	T. Boddaert, Y. Coquerel, J. Rodriguez, Chem. Eur. J. 2011, 17, 2266-2271.
Expeditious Divergent Synthetic Approach to Polycyclic Terpene-like Molecules	T. Boddaert, Y. Coquerel, J. Rodriguez, Chem. Eur. J. 2011, 17, 2048-2051.
Periselectivity Switch of Acylketenes in Cycloadditions with 1-Azadienes: Microwave-Assisted Diastereoselective Domino Three-Component Synthesis of alpha-Spiro-delta-lactams	Marc Presset, Yoann Coquerel, Jean Rodriguez, Org. Lett. 2010, 12, 4212-4215.
Utilisation des dérivés 1,3-dicarbonylés dans les réactions domino et multicomposé	Damien Bonne, Thierry Constantieux, Yoann Coquerel, Jean Rodriguez Techniques de l'Ingénieur 2010, CHV2210
1,3-Dicarbonyl compounds in stereoselective domino and multicomponent reactions	Damien Bonne, Yoann Coquerel, Thierry Constantieux, Jean Rodriguez Tetrahedron: Asymmetry 2010, 21, 1085–1109
Quadrane Sesquiterpenes: Natural Sources, Biology, and Syntheses	Marc Presset, Yoann Coquerel, Jean Rodriguez Eur. J. Org. Chem. (microreview) 2010, 2247-2260.
Multiple Bond-Forming Transformations: the Key Concept towards Eco-compatible Synthetic Organic Chemistry	Yoann Coquerel, Thomas Boddaert, Marc Presset, Damien Mailhol, Jean Rodriguez in Ideas in Chemistry and Molecular Sciences, Vol.1 Advances in synthetic chemistry, Chap 9, pp 187-202, Pignataro B. Ed.; Wiley-VCH, Weinheim, 2010.
Microwave-Assisted Domino and Multicomponent Reactions with Cyclic Acylketenes: Expeditious Syntheses of Oxazinones and Oxazindiones	Presset, M.; Coquerel, Y.; Rodriguez, J. Org. Lett. 2009, 11, 5706-5709
Consecutive reactions with sulfoximines: A direct access to 2-sulfonimidoylylidene tetrahydrofurans and 6-sulfonimidoylmethyl-3,4-dihydro-2H-pyrans	M.-A. Virolleaud, V. Sridharan, D. Mailhol, D. Bonne, C. Bressy, G. Chouraqui, L. Commeiras, Y. Coquerel, J. Rodriguez Tetrahedron, 2009, 65, 9756-9764.
Organocatalytic Activity of N-Heterocyclic Carbenes in the Michael Addition of 1,3-Dicarbonyls: Application to a Stereoselective Spirocyclization Sequence	Thomas Boddaert, Yoann Coquerel, Jean Rodriguez Adv. Synth. Catal. 2009, 351, 1744-1748.
Microwave-assisted Cross-metathesis of Acrylonitrile	Thomas Boddaert, Yoann Coquerel, Jean Rodriguez C. R. Chimie 2009, 12, 872-875.
Microwave-Assisted Wolff Rearrangement of Cyclic 2-Diazo-1,3-Diketones: An Eco-compatible Route to alpha-Carbonylated Cycloalkanones	Marc Presset, Yoann Coquerel, jean Rodriguez J. Org. Chem. 2009, 74, 415-418,
Microwave-Assisted Olefin Metathesis	Yoann Coquerel, Jean Rodriguez Eur. J. Org. Chem. (microreview) 2008, 1125-1132
Synthetic Studies Towards Guaianolide Sesquiterpene Lactones	Isabelle Reboul, Thomas Boddaert, Yoann Coquerel, Jean Rodriguez Eur. J. Org. Chem. 2008, 5379-5382
Stereoselective Synthesis of Bicyclo[4.2.1]nonanes: a Temporary-Bridge Approach to Cyclooctanoids	Antoine Michaut, Sonia Miranda-García, J. Carlos Menéndez,Yoann Coquerel, Jean Rodriguez Eur. J. Org. Chem. 2008, 4988-4998.
Catalytic Properties of the Pd/C – Triethylamine System	Yoann Coquerel, Jean Rodriguez Arkivoc 2008 (xi) 227-237.
The MARDi cascade : A Michael-Initiated Domino-Multicomponent Approach for the Stereoselective Synthesis of Seven-Membered Rings	Y. Coquerel, M.-H. Filippini, D. Bensa, J. Rodriguez Chem. Eur. J. 2008, 14, 3078-3092
Reluctant Cross-Metathesis Reactions: a Highly Beneficial Effect of Microwave Irradiation	Michaut, A,; Boddaert, T.; Coquerel, Y.; Rodriguez, J. Synthesis 2007, 2867-2871
Pd-H from Pd/C and Triethylamine: Implications in Palladium Catalysed Reactions Involving Amines	Coquerel, Y.; Brémond, P.; Rodriguez, J. J. Organomet. Chem. 2007, 692, 4805-4808.
Stereoselective Synthesis of the Core of Naturally Occurring Anti-HIV Isolitseane B	Brémond, P.; Girardeau, E.; Coquerel, Y.; Rodriguez Lett. Org. Chem. 2007, 4, 232-233
Synthetic Studies on the MARDi cascade: Stereoselective Synthesis of Heterocyclic Seven-Membered Rings.	Coquerel, Y., Bensa, D., Doutheau, A., Rodriguez, J. Org. Lett. 2006, 8, 4819-4822
Synthetic Studies on the MARDi cascade: Stereoselective Preparation of Sulfonyl Substituted Seven-Membered Rings	Coquerel, Y., Bensa, D., Moret, V., Rodriguez, J. Synlett 2006, 2751-2754.
Synthèse totale de terpénoïdes naturels possédant le squelette bicyclo [5.3.0]décane.	Carret, S., Coquerel, Y., Giannini, A., Sainte-Luce Banchelin, T., Deprés, J.-P. L'Act. Chim. 2006, 294, 23.
Chemo- and Regioselective Synthesis of 2-Alkylidenetetrahydrofurans Bearing a Chiral Sulfur Atom by Domino Reactions of Sulfoximines	Coquerel, Y., Rodriguez, J. Tetrahedron Lett. 2006, 47, 8503-8506.
Chemistry of Seven Membered Ring Ligands in Transition Metal Carbonyl Complexes	Coquerel, Y., Deprés, J.-P. in Frontiers in Organometallic Chemistry, Chap. 6, pp. 123-154, Cato, M. A. Ed., 2006 Nova Science Publishers, Hauppauge NY.
Approach to the Blues: a Highly Flexible Route to the Azulenes	Carret, S., Blanc, A., Coquerel, Y., Berthod, M., Greene, A. E., Deprés, J.-P. Angew. Chem., Int. Ed. 2005, 44, 5130.
Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study	Devergnas, S., Chimienti, F., Naud, N., Pennequin, A., Coquerel, Y., Chantegrel, J., Favier, A., Seve, M. Biochem. Pharmacol. 2004, 68, 699.
Access to diversely alpha-substituted cyclopentenones from a-chlorocyclopentenones	Giannini, A., Coquerel, Y., Greene, A. E., Deprés, J.-P. Tetrahedron Lett. 2004, 45, 6749.
New Approach to Bicyclo[5.3.0]decanes: Stereoselective Guaiane Synthesis.	Coquerel, Y., Greene, A. E., Deprés, J.-P. Org. Lett. 2003, 5, 4453.
Reductive complexation of cycloheptatrienes by iron pentacarbonyl and catalytic sodium borohydride	Coquerel, Y., Deprés, J.-P. Chem. Comm. 2002, 658.
Iron pentacarbonyl Fe(CO)5	Coquerel, Y. Synlett 2002, 1937.
Addition of Organolithium Compounds to Tricarbonyl(tropone)iron Complexes : Experimental and Structural Studies	Coquerel, Y., Deprés, J.-P., Greene, A. E., Philouze, C. J. Organomet. Chem. 2002, 659, 176.
Synthesis of Substituted Cycloheptadienes by Catalytic Hydrogenation of Cycloheptatrieneiron Complexes	Coquerel, Y., Deprés, J.-P., Greene, A. E., Cividino, P., Court, J. Synth. Commun. 2001, 31,1291.
(1R,2S,3S,6R,9S)-5,5,10,10-Tetrachloro-2-methyltricyclo[7.2.0.03,6]undec-7-ene-4,11-dione	Coquerel, Y., Blanc, A., Deprés, J.-P., Greene, A. E., Averbuch, M.-T., Philouze, C., Durif, A. Acta Cryst. 2000, C56, 1480