ism2 institut des sciences moléculaires de marseille, équipe BiosCiences

Centre national de la recherche Scientifique

Dr. Marius REGLIER

AMU iSm2 Service 342
Campus Scientifique de St Jérôme
13397 Marseille cedex 20

Téléphone : 0491 28 88 23

Fax : 0491 28 84 40

Courriel : marius.reglier@univ-amu.fr

Autre site Web : www.biosciences.univ-cezanne.fr

Parcours

1976 : Ingénieur Chimiste, Ecole Supérieure de Chimie de Marseille
1980 : Thèse de Docteur-Ingénieur, Université Paul Cézanne
1980-84 : Attaché de Recherche au CNRS, Ecole Normale Supérieure, ER12 S. Julia Université Pierre and Marie Curie (Paris VI)
1984 : Thèse d’Etat, Université Pierre and Marie Curie (Paris VI)
1985-87 : Chercheur associé, Université de Genève, Suisse, W. Oppolzer
1989-90 : Chercheur associé, Laboratoire de Neurobiology Moléculaire et Cellulaire, Gif/Yvette, J. Mallet
1992 : Visiting scientist, Johns Hopkins Univ., Baltimore, USA, K. D. Karlin
1986-2011 : Université Paul Cézanne, Chargé (CR1 1986), Directeur de Recherche au CNRS (DR2, 1994 et DR1, 2008)
2012- : Aix-Marseille Université
Distinctions :
2002 : Prix du “Docteur et de Madame Henri Labbé” de l’Académie des Sciences
2002 : Japan Society for the Promotion of Science (JSPS) fellowship

Enseignements

Thématiques

Métalloenzymes ; Monooxygénases et oxydases à cuivre : Tyrosinase (Ty), Dopamine -Hydroxylase (DH), Peptidylglycine -Amidating Monooxygenase (PAM), particulate Methane MonoOxygenase (pMMO), laccases (Lacc) ; Hydrogénases à FeFe et NiFe ; Enzymes à Fer non-hémique, ACC oxidase (ACCO)

Développement de modèles biomimétiques fonctionnels et structuraux et de systèmes bioinspirés
Enzymes artificielles
Etudes d’effecteurs enzymatiques (substrats, activateurs, inhibiteurs)
Purification et expression génétique

Responsabilités administratives

1996-2004 : membre du comité d’organisation des REncontres de Chimie Organique Biologique (Président pour le RECOB8, 2000)
2000-2004 : Membre nommé Comité National section 20
2001-2006 : Président du GIS CNRS/Univ. Paul Cézanne « Club CNRS Métalloprotéines et Modèles
2006-2011 : Membre du comité scientifique du Centre Franco-Indien pour la Recherche Avancée (CEFIPRA/IFCPAR)
2006-2008 : Directeur de la FRE CNRS 3005 BiosCiences
2007-2009 : Membre du comité ANR Programme blanc
2009-2012 : Vice président du programme ANR Retour Post-doctorant
2012- : Chargé de mission à l’Institut de Chimie du CNRS

Publications

Titre	Auteurs
Visible Light-Driven O2 Reduction by a Porphyrin-Laccase System	Theodore Lazarides; Igor Sazanovich; A. Jalila Simaan; Maria Chrisanthi Kafentzi; Milan Delor; Yasmina Mekmouche; Bruno Faure; Marius Réglier; Julia Weinstein; Athanassios Coutsolelos; Thierry Tron J. Am. Chem. Soc. 2013, 135, 3095?3103
Structural and magnetic characterization of a tetranuclear copper(II) cubane stabilized by intra-molecular metal cation-? interactions	Papadakis, Raffaello; Riviere, Eric; Giorgi, Michel; Rousselot-Pailley, Pierre; Réglier, Marius; Simaan, A. Jalila; Tron, Thierry Inorg. Chem. 2013, 52, 5824?5830
Binuclear copper(II) complexes 1: synthesis, characterization and evaluation of a new complex in phosphatase-like activity	Olivier Schicke, Bruno Faure, Michel Giorgi, A. Jalila Simaan, Marius Réglier; Inorg. Chim. Acta 2012, 391; 189–194
1-Aminocyclopropane-1-carboxylic acid oxidase: insight into cofactor binding from experimental and theoretical studies	Lydie Brisson Nadia El Bakkali-Taheri, Michel Giorgi, Antoine Fadel, József Kaizer, Marius Réglier, Thierry Tron, El Hassan Ajandouz, A. Jalila Simaan , J. Biol. Inorg. Chem., 2012 , 17, 939–949"
Photoinduced Multi-Electron Transfer to a Multicopper Oxidase Resulting in Dioxygen Reduction into Water	A. Jalila Simaan, Yasmina Mekmouche, Pierre Moreno, Ally Aukauloo, Jacques Delaire, Marius Réglier, Thierry Tron Chem. Eur. J. 2011, 17, 11743 – 11746
Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors	Langella E.; Pierre S.; Ghattas W.; Giorgi M.; Reglier M.; Saviano M.; Esposito L. and Hardré R. ChemMedChem, 2010, 5(9), 1568-76.
The Versatile Binding Mode of Transition-State Analogue Inhibitors of Tyrosinase towards Dicopper(II) Model Complexes: Experimental and Theoretical Investigations	Orio, M.; Bochot, C.; Dubois, C.; Gellon, G. ; Hardré, R.; Jamet, H.; Luneau, D.; Philouze, C.; Reglier, M.; Serratrice, G. Chemistry--A European Journal, 2011, 17(48), 13482-13494
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase	By Yi W.; Dubois C.; Yahiaoui S.; Haudecoeur R.; Belle C.; Song H.; Hardré R.; Reglier M.; Boumendjel A. Eur. J. Med. Chem. , 2011, 46(9), 4330-5
Synthesis and Characterization of a Binuclear Iron(III) Complex Bridged by 1-Aminocyclopropane-1-carboxylic Acid. Ethylene Production in the Presence of Hydrogen Peroxide	Wadih Ghattas, Zeinab Serhan, Nadia El Bakkali-Taheri, Marius Réglier, Masahito Kodera, Yutaka Hitomi, A. Jalila Simaan Inorg. Chem.. 2009, 48, 3910-3912
Binding of 2-Hydroxypyridine-N-oxide on Dicopper(II) Centers: Insights into Tyrosinase Inhibition Mechanism by Transition-State Analogs	E. Peyroux, W. Ghattas, R. Hardré, M. Giorgi, B. Faure, A. J. Simaan, C. Belle, M.Réglier.(2009) Inorg. Chem. 48, 10874-10876.
Molecular structure and catechol oxidase activity of a new copper(I) complex with sterically crowded monodentate N-donor ligand.	A. Kupan, J. Kaizer, G. Speier, M. Giorgi, M. Réglier, F. Pollreisz.(2009) J. Inorg. Biochem. 103, 389-395.
N-Hydroxyguanidines oxidation by a N3S copper-complex mimicking the reactivity of Dopamine beta-Hydroxylase.	P. Slama, J.-L. Boucher, M. Réglier.(2009) J. Inorg. Biochem. 103, 455-462.
Oxidative C-H and C-C Bond Cleavage by a (2,2'-Bipyridine)Copper(I) Chloride Complex.	Csonka R., Kaizer J., Giorgi M., Réglier M., Hajba, L., Mink J., Speier G. (2008) Inorganic Chemistry 47(14), 6121-6123.
Reduction of a N3S-copper complex by aromatic N-hydroxyguanidines : mimicking the reactivity of Dopamine ß-Hydroxylase	Slama P., Boucher J.-L., Réglier M. (2008) Journal of Inorganic Biochemistry, sous presse.
Identification of a copper(I) intermediate in the conversion of 1-aminocyclopropane carboxylic acid (ACC) into ethylene by Cu(II)-ACC complexes and hydrogen peroxide.	Ghattas W., Giorgi M., Mekmouche Y., Tanaka T., Rockenbauer A., Réglier M., Hitomi Y., Simaan A. J. (2008) Inorganic Chemistry 47(11), 4627-4638.
Cerium(IV)-mediated oxidation of flavonol with relevance to flavonol 2,4-dioxygenase. Direct evidence for spin delocalization in the flavonoxy radical.	Kaizer J., Ganszky I., Speier G., Rockenbauer A., Korecz L., Giorgi M., Réglier M., Antonczak S. (2007) Journal of Inorganic Biochemistry 101(6), 893-899.
Manganese and iron flavonolates as flavonol 2,4-dioxygenase mimics.	Kaizer J., Barath G., Pap J., Speier G., Giorgi M., Réglier M. (2007) Chemical Communications 48, 5235-5237.
New Functional Model Complexes of Intradiol-Cleaving Catechol Dioxygenases: Properties and Reactivity of Cu(II)(L)(O2Ncat).	J. Kaizer, Z. Zsigmond, I. Ganszky, G. Speier, M. Giorgi, M. Réglier(2007) Inorg. Chem. 46, 4660-4666.
Synthesis, structure and catalase mimics of novel homoleptic manganese(II) complexes of 1,3-bis(2'-pyridylimino)isoindoline, Mn(4R-ind)2 (R = H, Me).	Kaizer, Jozsef; Barath, Gabor; Speier, Gabor; Reglier, Marius; Giorgi, Michel. Inorganic Chemistry Communications (2007), 10(3), 292-294.
Xanthine oxidase-assisted catalysis by dopamine ?-hydroxylase: Mechanistic considerations on the role of superoxide anion.	Slama, Patrick; Reglier, Marius. Comptes Rendus Chimie (2007), 10(8), 731-741.
Characterization of Cu(II)-ACC complexes and conversion of the bound ACC into ethylene in the presence of hydrogen peroxide. Detection of a brown intermediate at low temperature	W. Ghattas, M. Giorgi, C. Gaudin, A. Rockenbauer, M. Réglier, A. J. Simaan Bioinorg. Chem. Appl. 2007, ID 43424
New insights in the mechanism of the dioxygen activation catalyzed by the Dopamine beta-monoxygenase.	P. Slama, M. Réglier(2007) C. R. Chimie 10, 731-741.
ACC-Oxidase like activity of a copper(II)-ACC complex in the presence of Hydrogen Peroxide. Detection of a reaction intermediate at low temperature.	W. Ghattas, C. Gaudin, M. Giorgi, A. Rockenbauer, A. J. Simaan, M. Réglier Chem. Commun. 2006, 1027-1029.
Mono vs Binuclear Copper(II) Complexes in Phosphodiester Hydrolysis.	K. Selmeczi, M. Giorgi, G. Speier, M. Réglier. Eur. J. Inorg. Chem. 2006, 1022-1031.
(O-Benzoylsalicylato)copper(II) complexes as synthetic enzyme-product models for flavonol 2,4-dioxygenase.	Kaizer, S. Góger, G. Speier, M. Réglier, M. Giorgi Inorg. Chem. Comm. 2006, 9, 251-254.
Preparation and X-ray Structure of a Catecholato Copper(II) Complex with a Schönberg Adduct.	B. Tapodi, G. Speier, M. Giorgi, M. Réglier, T. Funabiki, L. Korecz, A. Rockenbauer. Inorg. Chem. Comm. 2006, 9, 367-370.
{Chloro-[N-benzyl-bis-(2-pyridyl-methyl)amino]-copper(II)} perchlorate,[Cu(bnbpa)Cl]ClO4.	J. Kaizer, S. Góger, G. Speier, M. Giorgi, M. Réglier. Z. Kristallogr. NCS, 2006, 221, 75-76.
Pathway for the stereocontrolled Z and E production of alpha,alpha-difluorine-substituted phenyl butenoates	Ghattas W, Hess CR, Iacazio G, Hardré R, Klinman JP, Reglier M., J Org Chem. 2006, 71(22), 8618-21
LAC3, a new low redox potential laccase from Trametes C30 obtained as a recombinant protein in yeast.	A. Klonowska, C. Gaudin, M. Asso, A. Fournel, M. Réglier, T. Tron Enzyme and Microbial Technology, 2005, 36, 34-41.
Synthesis, structure and spectral properties of a novel stable homoleptic iron(II) complex of 1,3-bis(2'-pyridylimino)isoindoline, Fe(ind)2.	É. Balogh-Hergovich, G. Speier, M. Réglier, M. Giorgi, E. Kuzmann, A. Vértes Inorg. Chem. Comm. 2005, 8, 457-459.
Synthesis, structure and catecholase-like activity of anew dicopper(II) complex with benzoylacetonate ligand.	J. Kaizer, R. Csonka, G. Speier, M. Giorgi, M. Réglier J. Mol. Catal. A-Chem. 2005, 235, 81-87.
Synthesis, structure and catalase-like activity of new dicopper(II) complexes with phenylglyoxylate and benzoate ligands.	J. Kaizer, R. Csonka, G. Speier, M. Giorgi, M. Réglier J. Mol. Catal. A-Chem. 2005, 236, 12-17.
Copper-catalyzed oxygenation of 3-hydroxy-2-phenylquinolin-4(1H)-one: Synthesis, structure and spectral properties of [Cu(idpa)(N-baa)]ClO4, [idpa=3,3'-iminobis(N,N-dimethylpropylamine), N-baaH = N-benzoylanthranilic acid]	J. Kaizer, T. Csay, M. Czaun, G. Speier, M. Reglier, M. Giorgi Inorg. Chem. Comm. 2005, 8, 813-816.
A Diiron Center Stabilized by a Bis-TPA Ligand as a Model of Soluble Methane Monooxygenase: Predominant Alkene Epoxidation with H2O2	M. Kodera, M. Itoh, K. Kano, T. Funabiki, M. Réglier Angew. Chem. Int. Ed. Engl. 2005, 44, 7104-7106.
Chemo-enzymatic synthesis of all four diastereoisomers of 1-fluoro-2-amino-indan.	G. Iacazio, M. Réglier Tetrahedron: asymmetry 2005, 16, 3633-3639.
Kinetic studies of dicopper complexes in catechol oxidase model reaction by the use of the computer fitness software ZiTa.	K. Selmeczi, M. Réglier, G. Speier, G. Peintler Reaction Kinetics and Catalysis Letters 2004, 81(1), 143-151.
N-Aryl-N'-hydroxyguanidines: a new family of reduction cofactors for Dopamine ?-Hydroxylase.	P. Slama, J.-L. Boucher, M. Réglier Biochemical and Biophysical Chemical Research 2004, 316(4), 1081-1087.
Synthesis, structure and characterization of new complexes [Fe2( -OMe)2(PAP)(X)4] (PAP = 1,4-di(2'-pyridyl)aminophthalazine, X = Cl, OAc) and their oxidation catalysis.	E. Balogh-Hergovich, G. Speier, M. Reglier, M. Giorgi, E. Kuzmann, A. Vertes. Inorganica Chimica Acta, 2004, 357(12), 3689-3696.
Crystal structure of [N,N-bis(2-[2-pyridyl]ethyl)-2-(2-aminoethoxy)ethanol]-copper(II) bis(trifluoromethanesulfonate), (CuC18H25N3O2)(F3CSO3)2.	K. Selmeczi, G. Speier, M. Reglier, M. Giorgi. Zeitschrift fuer Kristallographie - New Crystal Structures 2004, 219(2), 143-144.
The facile formation of trioxanaphthacenes by a [4 + 2] addition of flavonols to 1,2-benzoquinone.	J. Kaizer, G. Speier, E. Ösz, M. Giorgi, M. Réglier Tetrahedron Lett. 2004, 45, 8011-8013.
Synthesis, properties, and crystal structure of a novel 3-hydroxy-(4H)-benzopyran-4-one containing copper(II) complex, and its oxygenation and relevance to quercetinase	J. Kaizer, J. Pap, G. Speier, M. Réglier, M. Giorgi Transition Metal Chemistry, 2004, 29, 630-633.
Synthesis, Structure, and Catalytic Activity of New µ-Oxo-Bridged Diiron(III) Complexes. E. Balogh-Hergovich,	G. Speier, M. Réglier, M. Giorgi, E. Kuzmann, A. Vertes. Eur. J. Inorg. Chem. 2003, 1735-1740.
Catechol oxidase activity of dicopper complexes with N-donor ligands.	K. Selmeczi, M. Réglier, M. Giorgi, G. Speier, G. Peintler.Coord. Chem. Rev. 2003, 245(1-2), 191-201.
Aminoindanes in oxygen transfer reactions, 3. Copper complexes as functional models for dopamine ? -hydroxylase - mechanistic study of oxygen atom transfer from Cu/O species to benzylic C-H bonds	Blain, Ingrid; Giorgi, Michel; De Riggi, Innocenzo; Reglier, Marius. European Journal of Inorganic Chemistry (2001), (1), 205-211.
Substrate-binding ligand approach in chemical modeling of copper-containing monooxygenases. Part 1. Intramolecular stereoselective oxygen atom insertion into a non-activated C-H bond	Blain, Ingrid; Giorgi, Michel; De Riggi, Innocenzo; Reglier, Marius. European Journal of Inorganic Chemistry (2000), (2), 393-398

Page modifiée le Mercredi 4 Avril, 2012